It was evident that GSE disrupts the bacterial membrane and liberates the cytoplasmic contents within 15 minutes after contact even at more dilute concentrations. With the aid of scanning transmission electron microscopy (STEM), the mechanism of GSE's antibacterial activity was revealed. However, test results indicated that at the 1:512 dilution, GSE remained bactericidal, but completely nontoxic.Ĭonclusions: The initial data shows GSE to have antimicrobial properties against a wide range of gram-negative and gram-positive organisms at dilutions found to be safe. Generally speaking grapefruit seed extract is made through the processing of grapefruit seeds and pulp with the addition of glycerin. Abstract Objectives: Recent testimonials report grapefruit-seed extract, or GSE (Citricidal) to be effective against more than 800 bacterial and viral strains, 100 strains of fungus, and a large number of single and multicelled parasites. The commercialized version of GSE is known as Citricidal. This is a citrus tree of the Rutaceae family that produces edible fruit. Grapefruit ( Citrus paradisi) seeds comes from a grapefruit, which comes from a grapefruit tree. While there has been no scientific demonstration of efficacy, this extract has been claimed by some practitioners of alternative medicine to possess antibacterial, antiviral, and anti-fungal properties.
Results: These tests indicated that from the 1:1 through the 1:128 concentrations, GSE remained toxic as well as bactericidal. Grapefruit Seed Extract, also known as GSE, is a compound derived from the seeds of grapefruit that has long been used for it’s antimicrobial properties. Citrus seed extract, also known as grapefruit seed extract, has been shown to inhibit CYP3A4 which is important in breaking down atorvastatin. Grapefruit seed extract, also known as GSE or citrus seed extract, is derived from the seeds, pulp and white membranes of a grapefruit. Grapefruit seed extract (GSE), also known as citrus seed extract, is a liquid derived from the seeds, pulp, and white membranes of grapefruit.
#Grapefruit seed extract skin#
In vitro assays with human skin fibroblast cells were also performed at the same dilutions to determine toxicity. Grapefruit oil is applied to the skin for tired muscles, hair growth, toning the skin, and for acne and oily skin. This study investigated GSE for antibacterial activity at varying time intervals and concentration levels and tissue toxicity at varying concentrations in an effort to determine if a concentration existed that was both microbicidal and nontoxic and in what period of time.ĭesign: Gram-negative and gram-positive isolates were introduced into graduated dilutions of GSE (twofold concentrations ranging from 1:1, through 1:512) for determination of bacterial activity. Grapefruit seed extract is taken by mouth for bacterial, viral, and fungal infections including yeast infections. Objectives: Recent testimonials report grapefruit-seed extract, or GSE ® (Citricidal ®) to be effective against more than 800 bacterial and viral strains, 100 strains of fungus, and a large number of single and multicelled parasites. Suggested Use: As a dietary supplement, take 1 capsule twice daily, or as directed by your healthcare practitioner.
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